University of Cincinnati, College of Medicine
Department of Internal Medicine, Division of Infectious Diseases
The University of Cincinnati is a premier, public, urban research university; ranked as one of America's top 26 public research universities by the National Science Foundation. U.S. News has ranked UC in the Top Tier of America's Best Colleges. The Chronicle of Higher Education calls UC a "research heavyweight". Forbes, Delta Sky and Travel + Leisure magazines have named UC one of the most beautiful campuses. #HottestCollegeInAmerica
UC is one of the largest employers in the Cincinnati region, employing over 15,000 full time and part time faculty, staff and student workers.
The College of Medicine, Department of Internal Medicine, Division of Infectious Diseases, is currently accepting applications for a full time senior research assistant.
Job Summary:
A rare opening for a self-starting Senior Research Assistant in an established laboratory studying the metabolic pathways of the fungal pathogens in the Pneumocystis species; the host response to these lung dwelling fungi; and pre-clinical drug development for the treatment of the pneumonia caused by these fungi. The candidate should have a repertoire of molecular, immunological and biochemical skills that will be used to experimentally approach these fastidious organisms. Pneumocystis are obligate fungi that dwell in the lungs of mammals, but can cause a lethal pneumonia when the host's immune system becomes debilitated. Pneumocystis infects humans receiving therapy for chronic inflammatory diseases like rheumatoid arthritis; in patients after stem cell and solid organ transplants; and in some patients receiving cancer chemotherapy. There are few drugs with which to treat the infection and drug discovery is a major focus of the lab- using molecular approaches such as RNA-seq to discover new drug targets.
Primary Duties/Skills Needed:
- Small animal handling: Rodent anesthesia, IP and IM injections, intratracheal and intranasal inoculations, euthanasia, profusion, tissue collection and histologic examination of tissues
- Advanced molecular biological skills/techniques: RNA & DNA extractions, primer design and qPCR on tissue samples, sample prep for RNA-Seq
- Biochemical skills: FPLC and Anion Exchange Chromatography, radiolabeled efflux assay, ELISA and other enzyme assays
- Immunological skills: A basic understanding of the immune responses to pathogens with skills in cell isolation and labeling, flow cytometry, immunohistochemistry
- Tissue culture: Aseptic technique; mammalian cell culture
Minimum Qualifications:
- Academic degree in related area of research or equivalent combination education/experience.
Ideal Qualifications:
- Ohio Licensed Veterinary Technician and Bachelor's Degree in a related field is preferred
- Experience with management of a research laboratory; regulatory compliance in an academic setting; experience working with Pneumocystis sp . is preferred
- Excellent oral and written communication skills
- Proficiency in various computer and software applications preferred including GraphPad Prism, EndNote, Excel, Word, Powerpoint
- Ability to work independently and as team player is preferred
The University of Cincinnati, as a multi-national and culturally diverse university, is committed to providing an inclusive, equitable and diverse place of learning and employment. As part of a complete job application you will be asked to include a Contribution to Diversity and Inclusion statement.
As a UC employee, and an employee of an Ohio public institution, if hired you will not contribute to the federal Social Security system, other than contributions to Medicare. Instead, UC employees have the option to contribute to a state retirement plan (OPERS, STRS) or an alternative retirement plan (ARP).
The University of Cincinnati is an Affirmative Action / Equal Opportunity Employer / M / F / Veteran / Disabled.
REQ: 35552
SF:OMJ SF:OOD SF:RM SF:INS
Nearest Major Market: Cincinnati
Job Segment: Biochemistry, Lab Technician, Internal Medicine, Clinical Research, Science, Healthcare, Research
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