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Position Summary:
Research in the Farris lab at the Virginia Tech Carilion Research Institute ( VTCRI ) focuses on understanding how dendritically localized RNAs are regulated in the brain and how local translation promotes cell-type specific functions underlying learning and memory. In particular, we are currently focused on investigating dendritic RNAs in area CA2 of the hippocampus, a subregion that is resistant to long-term potentiation and cell-death, and is thought to be required for social memory. Given that a number of neurodevelopmental disorders are characterized by disruptions in social processing, investigating the post-transcriptional mechanisms critical to CA2 function and gaining a comprehensive molecular understanding of how social experiences are stored in the brain may lead to novel therapies relevant for individuals with social deficits.
Using a combination of mouse genetics to gain access to specific hippocampal cell-types, deep sequencing technologies to obtain a genome-wide view of transcription and translation, and single molecule imaging techniques to illuminate the processes regulating dendritic RNA in vivo, we hope to provide mechanistic insight on the behaviorally-induced synaptic modifications in CA2 that may be required for encoding social behavior.
A postdoctoral associate will be responsible for:
1. Research Conceptualization - With the guidance of the PI, take a lead role in the design of experiment methodology and methods.
2. Perform Research - Independently perform experiments using techniques including mouse behavior, next generation sequencing, high resolution confocal imaging on thick brain sections (expansion microscopy/tissue clearing), slice electrophysiology, and calcium imaging. Note that experience in one or more of these techniques is not required, but desirable.
3. Data Analysis - Analyzing the findings from research methods and transforming the results into formats appropriate for dissemination in peer reviewed publications or conference presentations or in formats that engender further analysis.
4. Research Publications - Preparation of text, tables, and graphical information as appropriate for dissemination in peer-reviewed publications, or presentation at professional conferences.
5. Mentor undergraduate students.

Required Qualifications:
1. PhD in molecular, computational or cellular biology, pharmacology, physiology, neuroscience, or a related field.
2. Excellent writing skills; particularly with respect to report writing and editing.
3. Creative, independent with excellent communication skills.

Preferred Qualifications:
1. Strong work habits and the ability to work independently as well as in a fast-paced research environment with a team
2. Strong research record as demonstrated by publications in peer-reviewed journals.
3. The ideal candidate for this position should have demonstrated experience (i.e. publications) in neuroscience, RNA biology, or computational biology.



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