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Position Summary:
The Enzyme Research and Drug Discovery Laboratory located in the Department of Biochemistry at Virginia Tech seeks candidates for a Research Associate position in the area of Mechanistic Enzymology. The successful candidates will be actively involved in an interdisciplinary team who will investigate enzyme mechanisms, inhibitor validation and characterization, perform X-ray crystallography analyses, collaborate with other biochemists in the group and outside VT, and administration of the laboratory. Candidates should have demonstrable skills in high-throughput screening, organic chemistry, and theories for biophysical sciences.
Duties and Responsibilities:
- Perform protein expression and purification for biochemical assays and crystallization
- Perform enzyme kinetic analyses including steady-state kinetic and rapid reaction kinetics
- Develop appropriate methods for the determination of the mechanism of action of enzymes
- Collaborate with scientists in the research group
- Provide expertise in design, optimization, verification, and documentation of enzyme assays
- Serve as mentor to undergraduate and graduate students in the laboratory.
- Lead and participate in outreach and educational activities, as well as developing instructional materials
- Author/co-author articles for publication and presentation in scientific journals
- Ensure all relevant safety policies and procedures are followed and appropriate training is acquired and maintained

Required Qualifications:
PhD in biophysics, chemistry, biology, or related area; Experience in computational biology and biophysical methods; Excellent publication record; Excellent written and oral communication skills; Ability to work independently with good task organizational skills for timely accomplishment of activities.

Preferred Qualifications:
Experience in successful determination of enzyme structure and mechanism, and molecular dynamics and simulation; Demonstrated experience in writing and publishing scientific literature; Experience in stopped-flow spectrophotometry and isothermal calorimetry; Experience with high-throughput screening and associated experiments; Ability to meet intermediate objectives towards the accomplishment of milestones for the advancement of concurrent projects.



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